HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-Isopropyl-4-(2-methyl-6-nitro-pyridin-3-yl)-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | 3-Bromo-2-methyl-6-nitropyridine | HCID 67426409 | — |
| Catalyst | Tetrabutylammonium Iodide | HCID 67553 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ammonia methanol | HCID 21705897 | — |
| Product | 1-Isopropyl-4-(2-methyl-6-nitro-pyridin-3-yl)-piperazine | HCID 67427195 | 172.2% |
Reaction Steps
Stir 3-bromo-2-methyl-6-nitro-pyridine (2.46 g), 1-isopropyl-piperazine (2.74 g), tetra-n-butyl ammonium iodide (418.69 mg) and potassium carbonate (1.72 g) in dimethyl sulfoxide (DMSO, 20 mL) at 65° C. overnight. Add EA and water, separate the phases and dry the organic layer over magnesium sulfate and remove the solvent under vacuum. Purify by strong cation exchange cartridge eluting with methanol and then methanol-NH3 2 N to afford 2.58 g of the title compound. MS (ES+): m/z=265 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855211B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-bb929361ce1d4a23adef5f6d10274b36 |
| Source note | uspto-grants-2010_12 |