HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Isopropyl-4-(2-methyl-6-nitro-pyridin-3-yl)-piperazine → 5-(4-Isopropyl-piperazin-1-yl)-6-methyl-pyridin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Isopropyl-4-(2-methyl-6-nitro-pyridin-3-yl)-piperazine | HCID 67427195 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(4-Isopropyl-piperazin-1-yl)-6-methyl-pyridin-2-ylamine | HCID 67426948 | 99.8% |
Reaction Steps
Stir 1-isopropyl-4-(2-methyl-6-nitro-pyridin-3-yl)-piperazine (2.52 g) and palladium over carbon 10% (600 mg) in methanol (38 mL) and EA (38 mL) under H2 (balloon) overnight. Filter over a celite pad and remove the solvent under vacuum. Purify by silica gel column chromatography eluting with DCM/methanol (0-10%) to afford 2.23 g of the title compound. MS (ES+): m/z=143 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855211B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-3c233a23998941b6bafcb62fb49edcd9 |
| Source note | uspto-grants-2010_12 |