反应详情

温度

100 °C

Add cyclopentanamine (32 mL) to a solution of 2,4-dibromo-1-nitro-benzene (20 g) in 1-butanol (160 mL). Heat the mixture at 100° C. overnight. Remove the solvent under vacuum, add water and extract with EA. Wash the organic layer sequentially with an aqueous saturated solution of sodium bicarbonate and then water. Dry over magnesium sulfate and remove the solvent under vacuum to afford 22 g of the title compound. MS (ES+): m/z=286 (M+H)+.

1. customRemove the solvent under vacuum
2. additionadd water
3. extractionextract with EA
4. washWash the organic layer sequentially with an aqueous saturated solution of sodium bicarbonate
5. dry with materialDry over magnesium sulfate
6. customremove the solvent under vacuum