2-Chloropyrimidine → 6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole

HRID 2264366Notes

Reaction equation

HRID 2264366 reaction equation
C(N1CCN(CC2C=CC(N[C:17]3[N:22]=[C:21]([C:23]4[CH:35]=[C:34]([F:36])[C:26]5[N:27]=[C:28]([CH3:33])[N:29]([CH:30]([CH3:32])[CH3:31])[C:25]=5[CH:24]=4)[C:20]([F:37])=[CH:19][N:18]=3)=NC=2)CC1)C.[Cl:38]C1N=CC=CN=1>>[Cl:38][C:17]1[N:22]=[C:21]([C:23]2[CH:35]=[C:34]([F:36])[C:26]3[N:27]=[C:28]([CH3:33])[N:29]([CH:30]([CH3:32])[CH3:31])[C:25]=3[CH:24]=2)[C:20]([F:37])=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 744042-ChloropyrimidineHCID 46220502N-{5-[(4-Ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-amine

Product 1

HCID 783582066-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole

Procedure

Prepare the following intermediates essentially as described for [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine below using the corresponding amine and chloro-pyrimidine derivatives:

Workup

  1. customPrepare the following intermediates essentially

Sources & evidence

ORD record
ord-635e505774ef46dab388477caa582a8b
Source dataset
uspto-grants-2010_12
Patent number
US07855211B2

Reaction notes

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