Benzoyl Peroxide → 3-Bromo-2-(bromomethyl)pyridine

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-bromo-2-methylpyridine (46.5 g, 0.27 mol) in CCl4 (800 mL) was added NBS (53 g, 0.297 mol) and benzoylperoxide (4.7 g) and refluxed for 2 h in presence of light. The reaction mixture was cooled to 50° C. and filtered off the solid succinimide. The filtrate was concentrated and the crude 6-bromo-2-bromomethylpyridine was used for the follow-up reaction.

Provenance & Evidence