2-Aminothiazole → HCID 11152144, compound

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	Sodium Carbonate	HCID 10340	—
Reactant	1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)	HCID 636044	—
Reactant	HCID 68686094	HCID 68686094	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Solvent	Dioxane toluene	HCID 21840791	—
Product	HCID 11152144	HCID 11152144	53%

Reaction Steps

A pressure tube was charged with 5-chloro-quinazolino[3,2-a]quinazolin-12-one (200 mg, 0.71 mmol), Pd2(dba)3 (25 mg, 0.028 mmol), Xantphos (25 mg, 0.043 mmol), 2-aminothiazole (71 mg, 0.85 mmol), Na2CO3 (fine powder, 71 mg, 0.85 mmol) and anhydrous dioxane/toluene (1:1, 5 mL). The mixture was stirred with heating at 100 deg C. for 17 hours. After this period the mixture was cooled, concentrated in vacuo and purified by preparative chromatography, to yield the desired product (TFA salt) as a yellow powder (130 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07855214B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-71f4093c2f374558a18760139c448643
Source note	uspto-grants-2010_12