2,4-Dichlorophenol → HCID 86615292, compound

HRID 2264398Notes

Reaction equation

HRID 2264398 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9](Cl)[N:8]=[C:7]([Cl:12])[N:6]=1)=[O:4].[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[OH:21]>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[C:9]([O:21][C:15]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=2[Cl:13])[N:8]=[C:7]([Cl:12])[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 84492,4-DichlorophenolHCID 239689Methyl 2,4-dichloropyrimidine-6-carboxylate

Product 1

HCID 86615292HCID 86615292, compoundYield 90%

Procedure

The title compound was prepared in analogy to examples described in WO 01/85700 A2 (Janssen Pharmaceutica) from 2,6-dichloro-pyrimidine-4-carboxylic acid methyl ester (commercially available) and 2,4-dichloro-phenol in 90% yield. MS (ISP): 335.0 [M+H]+.

Sources & evidence

ORD record
ord-c3acdde1f0d14998b0a9b88dd6b52392
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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