2-chloro-6,7-dimethoxy-4-piperidin-1-ylquinazoline → HCID 68781515, compound

Participants

Reaction Steps

A solution of 2-chloro-6,7-dimethoxy-4-piperidin-1-yl-quinazoline (30.8 mg, 0.10 mmol 1.0 equiv; commercially available) and 1-(3-ethoxy-4-methoxy-benzyl)-piperidin-4-ylamine (39.7 mg, 0.15 mmol, 1.5 equiv; intermediate A1) in ethylene glycol (2 mL) was heated by microwave irradiation to 220° C. for 20 min. Removal of the solvent under reduced pressure and purification by preparative HPLC on reversed phase eluting with a gradient of acetonitrile/water provided 8.7 mg (16%) of the title compound. MS (ISP): 391.4 [M+H]+.

Provenance & Evidence