HCID 68781024, compound → HCID 68781256, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(5-bromo-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (1.00 g, 2.80 mmol, 1.0 equiv), copper(I) cyanide (0.38 g, 4.20 mmol, 1.5 equiv), tris(dibenzylideneacetone)dipalladium(0) (0.58 g, 0.56 mmol, 0.2 equiv) and 1,1′-bis(diphenylphosphino)ferrocene (0.31 g, 0.56 mmol, 0.2 equiv) in DMAc (8 mL) was heated by microwave irradiation to 180° C. for 30 min. The organic phase was concentrated under reduced pressure and the residue purified by silica column chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of heptane/ethyl acetate providing 0.20 g (23%) of the title compound. MS (ISP): 304.4 [M+H]+.

Provenance & Evidence