Hydrochloric Acid → [4-(2-Fluoro-phenyl)-quinazolin-2-yl]-piperidin-4-yl-amine dihydrochloride

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Reaction Steps

A solution of 4-[4-(2-fluoro-phenyl)-quinazolin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.86 g, 2.04 mmol) in ethanol (5 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 322.9 [M+H]+.

Provenance & Evidence