HCID 68781498, compound → HCID 68778549, compound

Participants

Reaction Steps

A solution of 4-[6-chloro-4-(2-fluoro-phenyl)-quinazolin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.66 g, 1.44 mmol) in ethanol (5 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 356.9 [M+H]+.

Provenance & Evidence