HCID 68781645, compound → HCID 68781377, compound

Participants

Reaction Steps

A solution of 4-(6-chloro-4-morpholin-4-yl-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.6 g, 1.34 mmol) in ethanol (5 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 348.4 [M+H]+.

Provenance & Evidence