2-Chloro-4,6-dimethoxy-1,3,5-triazine → HCID 68783648, compound

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Reaction Steps

A mixture of 2-chloro-4,6-dimethoxy-[1,3,5]triazine (1.35 g, 7.68 mmol, 1.0 equiv; commercially available) and 4-amino-piperidine-1-carboxylic acid tert-butyl ester (2.00 g, 9.98 mmol, 1.3 equiv; commercially available) in acetonitrile (16 mL) was heated by microwave irradiation to 160° C. for 20 min. The organic phase was concentrated under reduced pressure and the residue extracted with ethyl acetate (3×50 mL) from a solution of 1 M NaOH (200 mL). The combined organic phases were dried over MgSO4 and concentrated by evaporation under reduced pressure yielding 2.60 g (100%) of the title compound. MS (ISP): 340.4 [M+H]+.

Provenance & Evidence