Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | HCID 86603758 | HCID 86603758 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 68967680 | HCID 68967680 | 100.9% |
Reaction Steps
To a stirred solution of 6-(2,3-dihydro-1H-inden-2-ylamino)nicotinaldehyde (160 mg) and malonic acid (84 mg) in pyridine (6 mL) was added piperidine (0.01 mL), and the mixture was stirred at 100° C. for 2 hours. The solvent was evaporated in vacuo and the resulting powder was collected by filtration to give (2E)-3-[6-(2,3-dihydro-1H-inden-2-ylamino)-3-pyridinyl]acrylic acid (190 mg) as a pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07557127B2 |
|---|
| Source dataset | uspto-grants-2009_07 |
|---|
| ORD ID | ord-da2b786a21b744e981ef8718c6f77d24 |
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| Source note | uspto-grants-2009_07 |
|---|
