HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 58972428, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 58972439 | HCID 58972439 | — |
| Reactant | HCID 68781601 | HCID 68781601 | — |
| Reactant | HCID 86615299 | HCID 86615299 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58972428 | HCID 58972428 | — |
Reaction Steps
The compound was prepared in analogy to the synthesis of 4-[4-(2-hydroxy-ethylamino)-6-methoxy-[1,3,5]triazin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (intermediate C26/step 2) from 4-(4-chloro-6-methoxy-[1,3,5]triazin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (intermediate C26/step 1) and methylamine (12 M solution in water) and N-ethyl diisopropylamine in acetonitrile at rt, followed by BOC cleavage in analogy to the procedure described for 2-[4-methoxy-6-(piperidin-4-ylamino)-[1,3,5]triazin-2-ylamino]-ethanol (intermediate C26/step 3). MS (ISP): 239.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855194B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-d39320385164414fa67b1c707ea8e941 |
| Source note | uspto-grants-2010_12 |