Thiophene-3-methanol → HCID 10199524, compound

Participants

Reaction Conditions

Reaction Steps

100 mg (0.26 mmol) of 2-amino-4-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-(methylsulfanyl)-3,5-pyridinedicarbonitrile [prepared analogously to Dyachenko et al., Russian Journal of Chemistry, Vol. 33, No. 7, 1997, pages 1014-1017 or Vol. 34, No. 4, 1998, pages 557-563] are, together with 181 mg (1.6 mmol) of potassium tert-butoxide and 184 mg (1.6 mmol) of 3-hydroxymethylthiophene, stirred at 50° C. for 4 h. After cooling, the reaction mixture is diluted with dichloromethane and washed with water. The organic phase is dried with sodium sulfate and concentrated under reduced pressure. The residue is crystallized from diethyl ether.

Provenance & Evidence