2-Aminothiazole → HCID 59596725, compound

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Reaction Steps

5-Formylamino-naphthalene-1-sulfonyl chloride (0.25 g, 0.93 mmol), 2-aminothiazole (0.09 g, 0.93 mmol) and pyridine (1.00 ml) were stirred under N2 at 25° C. for 19 h. The solution was purified via silica gel chromatography using 3% MeOH/97% CH2Cl2 to obtain 5-formylamino-naphthalene-1-sulfonic acid thiazol-2-ylamide as a white solid (150 mg, 49%). LC/MS (10-99% CH3CN), M/Z: M+1 obs=334.20; tR=1.93 min.

Provenance & Evidence