Ethyl Acetate → 6-(6-Methylamino-pyrimidin-4-yloxy)-3,4-dihydro-2H-quinoline-1-carboxylic acid (4-tert.butyl-phenyl)-amide

Participants

Reaction Steps

A solution of 90 mg (0.35 mMol) of 6-methylamino-4-(1,2,3,4-tetrahydro-quinolin-6-yloxy)-pyrimidine (Step 3.2) in 2 ml of THF and a solution of 63.3 mg (97%; 0-35 mMol) of 4-tert.butyl-phenyl-isocyanate in 4 ml ether are mixed and stirred for 30 min. After concentration of the reaction mixture, a chromatography (Combi Flash; hexane/EtOAc 1:2→EtOAc) gives the title compound: m.p.: 175-176° C.; MS: [M+1]+=432; Anal.: C,H,N.

Provenance & Evidence