Hexane → HCID 86618287, compound

HRID 2264574Notes

Reaction equation

HRID 2264574 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]2[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][C:5]=2[CH:4]=1.[F:14][C:15]([F:26])([F:25])[C:16]1[CH:17]=[C:18]([N:22]=[C:23]=[O:24])[CH:19]=[CH:20][CH:21]=1.CCCCCC>CCOCC>[F:14][C:15]([F:25])([F:26])[C:16]1[CH:17]=[C:18]([NH:22][C:23]([N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:13]=[CH:12][C:6]2=3)=[O:24])[CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 8058HexaneHCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 122348407-Methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride

Product 1

HCID 86618287HCID 86618287, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 2.0 g (11.3 mMol) of 7-methoxy-2,3,4,5-tetrahydro-1H-benzo[b]azepine [Monatsheft Chemie, 97 (1966),150] and 2.28 g (97%; 11.8 mMol) of 3-trifluoromethyl-phenyl-isocyanate in 20 ml ether is stirred for 30 min in a icebath. After addition of hexane, the mixture is concentrated partially in vacuo and the crystallized product filtered off: m.p.: 108° C.; MS: [M+1]+=365; Anal.: C,H,N,F.

Workup

  1. concentrationthe mixture is concentrated partially in vacuo
  2. filtrationthe crystallized product filtered off

Sources & evidence

ORD record
ord-94f522d45c6a484994e03fda98e610de
Source dataset
uspto-grants-2010_12
Patent number
US07855215B2

Reaction notes

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