HCID 59596383, compound → HCID 59596351, compound

Participants

Reaction Steps

0.65 mMol of 7-(6-azido-pyrimidin-4-yloxy)-2,3,4,5-tetrahydro-benzo[b]azepine-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide in 5 ml THF are hydrogenated in the presence of 0.1 g Pd/C (10% Engelhard 4505). Filtration and chromatography (Combi Flash; hexane/EtOAc 19:1→11:9→1:3) of the concentrated filtrate gives the title compound: MS: [M+1]+=444; HPLC: AtRet=10.6; Anal.: C,H,N,F.

Provenance & Evidence