HCID 58659388, compound → HCID 59596402, compound

Participants

Reaction Steps

A solution of 261 mg (0.60 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-2,3-dihydro-indole-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide (WO 03/099771; ex. 163) in 15 ml isopropylamin is stirred for 18 h at rt and then concentrated in vacuo. The residue is dissolved in EtOAc and water and the aqueous layer extracted twice with EtOAc. -The organic layers are washed with water and brine, dried (Na2SO4) and concentrated. Column chromatography (SiO2; EtOAc/hexane 1:1) gives the title compound: m.p.: 189° C.; MS: [M+1]+=458; TLC(EtOAc): Rf=0.45.

Provenance & Evidence