HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 5-((6-Chloropyrimidin-4-yl)oxy)-1H-indole | HCID 57455156 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole | HCID 86234704 | — |
Reaction Steps
490 mg (2.0 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-indole (WO 03/099771; Stage 163.1) and 260 mg (4.0 mMol) NaN3 in 3 ml DMF are stirred for 3 h at 90° C. Then the reaction mixture is poured into water and extracted three times with EtOAc. The organic layers are washed twice with water and brine, dried (Na2SO4) and concentrated, yielding the title compound: MS: [M+1]+=253.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855215B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-15e27e7259fb44428da90c0ce67e12f8 |
| Source note | uspto-grants-2010_12 |