Methylamine → HCID 67531068, compound

Participants

Reaction Steps

Dissolved in 6 ml methylamin solution (2 M in THF), 245 mg (1.0 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-indole (WO 03/099771; Stage 163.1) are stirred for 24 h at rt and 8.5 h at 50° C. The concentrated reaction mixture is dissolved in water and EtOAC, the aqueous layer separated off and extracted twice with EtOAc. The organic layers are washed with water and brine, dried (Na2SO4) and concentrated. Column chromatography (SiO2; EtOAc/hexane 1:1→3:1) gives the title compound: MS: [M+1]+=241; TLC(EtOAc): Rf=0.15.

Provenance & Evidence