HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-(2-Amino-pyrimidin-4-yloxy)-2,3-dihydro-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-(1H-5-indolyloxy)-2-pyrimidinamine | HCID 21949262 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-(2-Amino-pyrimidin-4-yloxy)-2,3-dihydro-1H-indole | HCID 67530291 | — |
Reaction Steps
A solution of 160 mg (0.70 mMol) of 5-(2-amino-pyrimidin-4-yloxy)-1H-indole in 4 ml acetic acid is cooled to 10-15° C. Then 222 mg (3.5 mMol) NaBH3CN are added. After 1 h stirring at rt, 8 g of ice are added. Then the mixture is made basic by addition of 1 N NaOH and extracted three times with EtOAc. The organic layers are washed with water and brine, dried (Na2SO4) and concentrated at rt in vacuo: MS: [M+1]+=229.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855215B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-59d0731eebbc4225b3ea77f6279d2465 |
| Source note | uspto-grants-2010_12 |