3-(Trifluoromethyl)phenyl isocyanate → HCID 59596411, compound

Participants

Reaction Steps

To a solution of 242 mg (1 mmol) 4-(1,2,3,4-tetrahydro-quinolin-6-yloxy)-pyrimidin-2-ylamine (Step 29.2) in 5 mL of dry THF are added 205 mg (1.1 mmol) of 3-trifluoromethyl-phenylisocyanate at RT. The solution is stirred for 2 h at RT and then the THF is evaporated. The residue is purified by flash-chromatography on silica gel using dichloromethane/methanol 95:5 as eluent. Fractions with pure compound are pooled and evaporated to give the title compound as an amorphous material: MS: [M+1]+=430; HPLC: CtRet=2.14; TLC (dichloromethane/methanol 95:5): Rf=0.45.

Provenance & Evidence