Water → HCID 86618291, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4.70 g (10.8 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-2,3-dihydro-indole-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide (WO 03/099771; Ex. 163) in 50 ml DMF, 1.4 g (21.6 mMol) NaN3 are added at rt. Then the mixture is stirred for 3 h at 70° C., cooled to rt and pored into water and extracted tree times with EtOAc. The organic layers are washed with water and brine, dried (Na2SO4) and concentrated, yielding the title compound: m.p.: 167-168° C.

Provenance & Evidence