Water → HCID 67529781, compound

Participants

Reaction Steps

A solution of 6.21 g (21.9 mMol) 6-(1H-indol-5-yloxy)-pyrimidine-4-carboxylic acid ethyl ester in 70 ml acetic acid is cooled in an ice bath. Then 6.88 g (109 mMol) NaBH3CN are added and stirring is continued for 1 h. After addition of 17 ml water, the mixture is concentrated in vacuo. The resulting brown oil is re-dissolved in EtOAc and a 1:1 mixture of water and sat. NaHCO3, the aqueous layer separeted off and extracted twice with EtOAc. The organic phases are washed with water and brine, dried (Na2SO4) and concentrated to the crude title compound: MS: [M+1]+=286.

Provenance & Evidence