HCID 10449116, compound → HCID 67044388, compound

HRID 2264629Notes

Reaction equation

HRID 2264629 reaction equation
[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2/[CH:19]=[CH:20]/[C:21]([OH:23])=[O:22])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.CO.[C].[Pd]>[C:1]1([S:7]([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[CH2:19][CH2:20][C:21]([OH:23])=[O:22])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 1

HCID 10449116HCID 10449116, compound

Product 1

HCID 67044388HCID 67044388, compoundYield 49.7%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

To a solution of 180 mg of (2E)-3-[1-(phenylsulfonyl)-1H-indol-2-yl]acrylic acid in 3 mL of ethanol and 5 mL of methanol, 50 mg of 10% palladium-carbon (wet, water content 53%) was added, and the resulting mixture was stirred under hydrogen atmosphere (1 atm) at room temperature for 2 hours. The catalyst was removed from the solution, the solvent was evaporated under reduced pressure, and the residue was washed with ether to obtain 90 mg of 3-[1-(phenylsulfonyl)-1H-indol-2-yl]propanoic acid as a white solid. FAB−: 328

Workup

  1. customThe catalyst was removed from the solution
  2. customthe solvent was evaporated under reduced pressure
  3. washthe residue was washed with ether

Sources & evidence

ORD record
ord-7dda4654c6cd45ee864130541938c55b
Source dataset
uspto-grants-2010_12
Patent number
US07855225B2

Reaction notes

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