Hydrochloride methanol → HCID 86603771, compound

HRID 226467Notes

Reaction equation

HRID 226467 reaction equation
[ClH:1].CO.[CH2:4]([N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]2[N:23]=[CH:22][C:21](/[CH:24]=[CH:25]/[C:26]([NH:28][O:29]C3CCCCO3)=[O:27])=[CH:20][CH:19]=2)[CH2:13][CH2:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO>[ClH:1].[ClH:1].[CH2:4]([N:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18]2[N:23]=[CH:22][C:21](/[CH:24]=[CH:25]/[C:26]([NH:28][OH:29])=[O:27])=[CH:20][CH:19]=2)[CH2:13][CH2:12]1)[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86603617HCID 86603617, compound

Product 1

HCID 86603771HCID 86603771, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

A solution of 10% HCl-MeOH solution (0.5 ml) was added to a mixture of (2E)-3-{6-[(1-benzyl-4-piperidyl)amino]-3-pyridyl}-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (180 mg) in MeOH (5 ml) and stirred at 15-25° C. for 2 hours. The reaction mixture was evaporated in vacuo and the residue was triturated with small amount MeOH and acetone and the precipitate was collected by filtration to give (2E)-3-{6-[(1-benzyl-4-piperidyl)amino]-3-pyridyl}-N-hydroxyacrylamide dihydrochloride (120 mg)

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. customthe residue was triturated with small amount MeOH and acetone
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-0c5b423c25fd437c8c2d055492084273
Source dataset
uspto-grants-2009_07
Patent number
US07557127B2

Reaction notes

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