2-chloro-N,N-dimethylacetamide → HCID 66591549, compound

HRID 2264671Notes

Reaction equation

HRID 2264671 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH2:17][CH:18]2[CH2:22][CH2:21][O:20][CH2:19]2)[CH2:11][C:12]([N:14]([CH3:16])[CH3:15])=[O:13])=[CH:4][C:3]=1[O:23][CH2:24][C:25]([F:28])([F:27])[F:26].[Cl:29][CH2:30][C:31](N1CCCC1)=O.ClCC(N(C)C)=O>>[ClH:29].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH2:17][CH:18]2[CH2:22][CH2:21][O:20][CH2:19]2)[CH2:11][C:12]([N:14]2[CH2:15][CH2:31][CH2:30][CH2:16]2)=[O:13])=[CH:4][C:3]=1[O:23][CH2:24][C:25]([F:26])([F:27])[F:28]

Participants

4

Reactant 3

HCID 758862-chloro-N,N-dimethylacetamideHCID 884401-(Chloroacetyl)pyrrolidineHCID 25018730HCID 25018730, compound

Product 1

HCID 66591549HCID 66591549, compoundYield 74%

Procedure

This compound was obtained as a brown solid in 74% yield following the same procedure described in Scheme 21 for the synthesis of 2-[[2-[4-fluoro-3-(2,2,2-trifluoro-ethoxy)-phenyl]-ethyl]-(tetrahydrofuran-3-ylmethyl)amino]-N,N-dimethyl-acetamide, using 2-chloro-1-pyrrolidin-1-yl-ethanone as the reagent instead of 2-chloro-N,N-dimethyl-acetamide.

Workup

  1. customThis compound was obtained as a brown solid in 74% yield

Sources & evidence

ORD record
ord-46f931db46b84959a1daf371aa64bf13
Source dataset
uspto-grants-2010_12
Patent number
US07855227B2

Reaction notes

Loading…