Trifluoroacetic acid → HCID 24875148, compound

Participants

Reaction Steps

To methanesulfonic acid 4-[1-(3-bromo-phenyl)-3-tert-butoxycarbonylamino-1H-isoindol-1-yl]-phenyl ester (Scheme #6, T) (730 mg, 1.31 mmol) was added 10% trifluoroacetic acid in dichloromethane (10 mL) and the reaction stirred 30 minutes. The solvents were removed under reduced pressure and the resulting oil put under high vacuum. Ether, 20 mL, was added to the gum and the solvent removed under reduced pressure giving the title compound (671 mg, 90%). 1H NMR (500 MHz, DMSO-d6) δ 8.32 (d, J=7.9 Hz, 1 H), 7.90-7.86 (m, 2 H), 7.76 (ddd, J=7.9, 6.1, 2.0 Hz, 1 H), 7.63 (d, J=8.0 Hz, 1 H), 7.46 (t, J=1.8 Hz, 1 H), 7.41-7.35 (m, 5 H), 7.31 (d, J=8.5 Hz, 1 H), 3.40 (d, J=4.0 Hz, 3 H); MS (ES+) m/z 457 [M+1]+; tR=1.84 min.

Provenance & Evidence