(Pyrimidin-5-yl)boronic acid → HCID 59596243, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromo-4-fluorophenyl)-1-pyridin-4-yl-1H-isoindol-3-amine (Scheme #11, G) as described in Example 67 (Scheme #10, D) in 41% yield using pyrimidin-5-ylboronic acid. 1H NMR (DMSO-d6) δ 9.02 (s, 1 H), 8.78-8.72 (m, 2 H), 8.30-8.23 (m, 2 H), 7.78-7.70 (m, 1 H), 7.66-7.58 (m, 1 H), 7.41-7.26 (m, 4 H), 7.20-7.08 (m, 3 H), 6.76 (br s, 2 H), 1.72 (s, 1.9 H); MS (ESI) m/z 382 [M+1]+.

Provenance & Evidence