3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 59596302, compound

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Reaction Steps

The title compound was synthesized from 1-(3-bromo-4-fluorophenyl)-1-pyridin-4-yl-1H-isoindol-3-amine (Scheme #11, G) as described in Example 67 (Scheme #10, D) in 31% yield using 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine. 1H NMR (DMSO-d6) δ 8.63 (d, J=2.78 Hz, 1 H), 8.57-8.51 (m, 1 H), 8.50-8.42 (m, 2 H), 7.95-7.86 (m, 2 H), 7.85-7.78 (m, 1 H), 7.56-7.46 (m, 4 H), 7.36-7.27 (m, 3 H), 6.96 (br s, 2 H), 1.91 (s, 2.5 H); MS (ESI) m/z 399 [M+1]+.

Provenance & Evidence