(Pyrimidin-5-yl)boronic acid → 1-Cyclopropyl-1-(3-pyrimidin-5-ylphenyl)-1H-isoindol-3-amine acetate

Participants

Reaction Steps

The title compound was prepared in 85% yield as described for Example 78 (Scheme #14, N) starting from 1-(3-bromophenyl)-1-cyclopropyl-1H-isoindol-3-amine acetate (Scheme #15, O) and pyrimidine-5-ylboronic acid: 1H NMR (DMSO-d6) δ 9.19 (s, 1 H), 9.10 (s, 2 H), 8.02 (t, J=1.76 Hz, 1 H), 7.77 (t, J=8.03 Hz, 2 H), 7.64 (dd, J=7.78, 1.25 Hz, 1 H), 7.60-7.55 (m, 1 H), 7.47-7.37 (m, 3 H), 2.05-1.94 (m, 1 H), 1.87 (s, 3 H), 0.52-0.41 (m, 2 H), 0.28-0.17 (m, 1 H), −0.04-0.05 (m, 1 H); MS (ES) m/z 327 [M+1]+.

Provenance & Evidence