2-Fluoro-5-methoxyphenylboronic acid → 1-(2'-Fluoro-5'-methoxybiphenyl-3-yl)-1-(3-fluoropyridin-4-yl)-1H-isoindol-3-amine

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(3-fluoropyridin-4-yl)-1H-isoindol-3-amine (Scheme #12, I) as described in Example 67 (Scheme #10, D) in 73% yield using 2-fluoro-5-methoxyphenylboronic acid. 1H NMR (DMSO-d6) δ 8.45 (d, J=2.78 Hz, 1 H), 8.34 (d, J=4.80 Hz, 1 H), 7.88-7.82 (m, 1 H), 7.77-7.69 (m, 1 H), 7.54-7.46 (m, 2 H), 7.45-7.30 (m, 4 H), 7.27-7.15 (m, 2 H), 7.04-6.85 (m, 4 H), 3.76 (s, 3 H); MS (ESI) m/z 428 [M+1]+.

Provenance & Evidence