反应详情

The title compound was synthesized from 1-(3-bromophenyl)-1-(3-fluoropyridin-4-yl)-1H-isoindol-3-amine (Scheme #12, I) as described in Example 67 (Scheme #10, D) in 69% yield using 2-fluoro-3-methoxyphenylboronic acid. 1H NMR (DMSO-d6) δ 8.26 (d, J=2.78 Hz, 1 H), 8.14 (d, J=5.05 Hz, 1 H), 7.67-7.61 (m, 1 H), 7.55-7.50 (m, 1 H), 7.34-7.28 (m, 2 H), 7.21-7.10 (m, 4 H), 7.07-6.92 (m, 3 H), 6.77 (br s, 2 H), 6.74-6.68 (m, 1 H), 3.65 (s, 3 H); MS (ESI) m/z 428 [M+1]+.