2-Fluoro-3-methoxyphenylboronic acid → 1-(2',6-Difluoro-3'-methoxybiphenyl-3-yl)-1-(3-fluoropyridin-4-yl)-1H-isoindol-3-amine

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromo-4-fluorophenyl)-1-(3-fluoropyridin-4-yl)-1H-isoindol-3-amine (Example 70) as described in Example 67 Scheme #10, D in 25% yield using 2-fluoro-3-methoxyphenyl boronic acid. 1H NMR (DMSO-d6) δ 8.39 (d, J=3.03 Hz, 1 H), 8.26 (d, J=5.05 Hz, 1 H), 7.83-7.73 (m, 1 H), 7.71-7.64 (m, 1H), 7.48-7.39 (m, 2 H), 7.29-7.11 (m, 6 H), 6.92 (br s, 2 H), 6.81-6.73 (m, 1 H), 3.79 (s, 3 H); MS (ESI) m/z 446 [M+1]+.

Provenance & Evidence