2-Fluoro-3-methoxyphenylboronic acid → 1-(2'-Fluoro-3'-methoxybiphenyl-3-yl)-1-pyridin-4-yl-1H-isoindol-3-amine

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-pyridin-4-yl-1H-isoindol-3-amine (Scheme #9, C) as described in Example 67 Scheme #10, D in 50% yield using 2-fluoro-3-methoxyphenyl boronic acid. 1H NMR (DMSO-d6) δ 8.42-8.32 (m, 2 H), 7.78-7.67 (m, 2 H), 7.44-7.34 (m, 3 H), 7.34-7.20 (m, 5 H), 7.15-7.02 (m, 2 H), 6.92-6.74 (m, 3 H), 3.78 (s, 3 H); MS (ESI) m/z 410 [M+1]+.

Provenance & Evidence