2-Fluoropyridine-3-boronic acid → 1-[3-(2-Fluoropyridin-3-yl)phenyl]-1-(2-methoxypyrimidin-5-yl)-1H-isoindol-3-amine

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-methoxypyrimidin-5-yl)-1H-isoindol-3-amine (Example 106) as described in Example 67 Scheme #10, D in 34% yield using 2-fluoropyridine-3-boronic acid. 1H NMR (DMSO-d6) δ 8.47 (s, 2 H), 8.19-8.13 (m, 1 H), 8.01-7.91 (m, 1 H), 7.88-7.81 (m, 1 H), 7.77 (d, J=5.56 Hz, 1 H), 7.52-7.48 (m, 1 H), 7.46-7.32 (m, 6 H), 6.88 (br s, 2 H), 3.80 (s, 3 H); MS (ESI) m/z 412 [M+1]+.

Provenance & Evidence