(Pyrimidin-5-yl)boronic acid → 1-(2-Methoxypyrimidin-5-yl)-1-(3-pyrimidin-5-ylphenyl)-1H-isoindol-3-amine

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-methoxypyrimidin-5-yl)-1H-isoindol-3-amine (Example 106) as described in Example 67 Scheme #10, D in 54% yield using pyrimidine-5-boronic acid. 1H NMR (DMSO-d6) δ 9.18 (s, 1 H), 9.05 (s, 2H), 8.55 (s, 2 H), 7.98-8.11 (m, 1 H), 7.79-7.88 (m, 1 H), 7.70-7.77 (m, 1 H), 7.67 (d, J=7.58 Hz, 1 H), 7.41-7.57 (m, 4 H), 6.96 (br s, 2 H), 3.87 (s, 3 H); MS (ESI) m/z 395 [M+1]+.

Provenance & Evidence