(Pyrimidin-5-yl)boronic acid → HCID 24874778, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-ethylpyridin-4-yl)-1H-isoindol-3-amine (Example 110) as described in Example 67 Scheme #10, D in 58% yield using pyrimidine-5-boronic acid. 1H NMR (DMSO-d6) δ 9.11 (s, 1 H), 8.93 (s, 2 H), 8.28 (d, J=5.30 Hz, 1 H), 7.86 (dd, J=6.06, 1.77 Hz, 1 H), 7.80-7.68 (m, 1 H), 7.64-7.54 (m, 2 H), 7.47-7.36 (m, 4 H), 7.19-7.10 (m, 1 H), 7.07 (dd, J=5.18, 1.64 Hz, 1 H), 6.85 (br s, 2 H), 2.59 (q, J=7.58 Hz, 2 H), 1.08 (t, J=7.58 Hz, 3 H); MS (ESI) m/z 392 [M+1]+.

Provenance & Evidence