2-Fluoropyridine-3-boronic acid → HCID 24874779, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-ethylpyridin-4-yl)-1H-isoindol-3-amine (Example 110) as described in Example 67 Scheme #10, D in 61% yield using 2-fluoropyridine-3-boronic acid. 1H NMR (DMSO-d6) δ 8.28 (d, J=5.31 Hz, 1 H), 8.20-8.11 (m, 1 H), 7.98-7.89 (m, 1 H), 7.79-7.71 (m, 2 H), 7.47-7.28 (m, 7 H), 7.15-7.10 (m, 1 H), 7.06 (dd, J=5.18, 1.64 Hz, 1 H), 6.83 (br s, 2 H), 2.60 (q, J=7.58 Hz, 2 H), 1.08 (t, J=7.58 Hz, 3 H); MS (ESI) m/z 409 [M+1]+.

Provenance & Evidence