(Pyrimidin-5-yl)boronic acid → HCID 24874780, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-isopropylpyridin-4-yl)-1H-isoindol-3-amine (Example 113) as described in Example 67 Scheme #10, D in 58% yield using pyrimidine-5-boronic acid. 1H NMR (DMSO-d6) δ 9.11 (s, 1 H), 8.93 (s, 2 H), 8.30 (d, J=5.30 Hz, 1 H), 7.90-7.82 (m, 1 H), 7.81-7.69 (m, 1 H), 7.65-7.53 (m, 2 H), 7.49-7.33 (m, 4 H), 7.17-7.11 (m, 1 H), 7.07 (dd, J=5.31, 1.77 Hz, 1 H), 6.86 (br s, 2 H), 2.97-2.75 (m, 1 H), 1.08 (d, J=6.82 Hz, 6 H); MS (ESI) m/z 406 [M+1]+.

Provenance & Evidence