2-Fluoropyridine-3-boronic acid → HCID 24874781, compound

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Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-isopropylpyridin-4-yl)-1H-isoindol-3-amine (Example 113) as described in Example 67 Scheme #10, D in 42% yield using 2-fluoropyridine-3-boronic acid. 1H NMR (DMSO-d6) δ 8.29 (d, J=5.30 Hz, 1 H), 8.19-8.11 (m, 1 H), 7.97-7.90 (m, 1 H), 7.82-7.70 (m, 2 H), 7.49-7.27 (m, 7 H), 7.18-7.11 (m, 1 H), 7.05 (dd, J=5.31, 1.77 Hz, 1 H), 6.84 (br s, 2 H), 2.93-2.77 (m, 1 H), 1.08 (d, J=6.82 Hz, 6 H); MS (ESI) m/z 423 [M+1]+.

Provenance & Evidence