2-Fluoropyridine-3-boronic acid → HCID 24874820, compound

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Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-chloropyridin-4-yl)-1H-isoindol-3-amine (Example 120) as described in Example 67 Scheme #10, D in 35% yield using 2-fluoropyridine-3-boronic acid. 1H NMR (DMSO-d6) δ 8.32 (d, J=5.31 Hz, 1 H), 8.27-8.19 (m, 1 H), 8.08-7.99 (m, 1 H), 7.96-7.81 (m, 2 H), 7.61-7.31 (m, 9 H), 7.01 (br s, 2 H); MS (ESI) m/z 415 [M+1]+.

Provenance & Evidence