(Pyrimidin-5-yl)boronic acid → HCID 24874821, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(2-chloropyridin-4-yl)-1H-isoindol-3-amine (Example 120) as described in Example 67 Scheme #10, D in 51% yield using pyrimidine-5-boronic acid. 1H NMR (DMSO-d6) δ 9.18 (s, 1 H), 9.04 (s, 2 H), 8.31 (d, J=5.30 Hz, 1 H), 8.06-7.94 (m, 1 H), 7.89-7.81 (m, 1 H), 7.72-7.65 (m, 2 H), 7.57-7.45 (m, 4 H), 7.38 (dd, J=5.31, 1.52 Hz, 1 H), 7.36-7.33 (m, 1 H), 7.01 (br s, 2 H); MS (ESI) m/z 398 [M+1]+.

Provenance & Evidence