(Pyrimidin-5-yl)boronic acid → HCID 24874823, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromophenyl)-1-(5-fluoropyridin-3-yl)-1H-isoindol-3-amine (Example 123) as described in Example 67 Scheme #10, D in 41% yield using pyrimidine-5-boronic acid. 1H NMR (DMSO-d6) δ 9.18 (s, 1 H), 9.04 (s, 2 H), 8.49 (t, J=1.77 Hz, 1 H), 8.45 (d, J=2.53 Hz, 1 H), 8.08-8.02 (m, 1 H), 7.90-7.80 (m, 1 H), 7.74-7.64 (m, 2 H), 7.62-7.43 (m, 5 H), 6.98 (br s, 2 H); MS (ESI) m/z 382 [M+1]+.

Provenance & Evidence