(Pyrimidin-5-yl)boronic acid → HCID 24874824, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromo-4-fluorophenyl)-1-(4-methoxy-3-methylphenyl)-1H-isoindol-3-amine (Example 126) as described in Example 67 Scheme #10, D in 41% yield using pyrimidine-5-boronic acid. 1H NMR (DMSO-d6) δ 9.07 (s, 1 H), 8.78 (d, J=1.26 Hz, 2 H), 7.76-7.61 (m, 2 H), 7.43-7.24 (m, 4 H), 7.22-7.11 (m, 1 H), 7.01-6.90 (m, 2 H), 6.88-6.54 (m, 3 H), 3.58 (s, 3 H), 1.92 (s, 3 H); MS (ESI) m/z 425 [M+1]+.

Provenance & Evidence