2-Fluoropyridine-3-boronic acid → HCID 24874825, compound

Participants

Reaction Steps

The title compound was synthesized from 1-(3-bromo-4-fluorophenyl)-1-(4-methoxy-3-methylphenyl)-1H-isoindol-3-amine (Example 126) as described in Example 67 Scheme #10, D in 5% yield using 2-fluoropyridine-3-boronic acid. 1H NMR (DMSO-d6) δ 8.54-8.46 (m, 1 H), 8.22-8.15 (m, 1 H), 8.05-7.84 (m, 2 H), 7.76-7.55 (m, 5 H), 7.53-7.41 (m, 1 H), 7.32-7.23 (m, 2 H), 7.08-6.78 (m, 3 H), 3.93 (s, 3 H), 2.27 (s, 3 H); MS (ESI) m/z 442 [M+1]+.

Provenance & Evidence