Potassium Carbonate → HCID 135985748, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 6-bromo-2-pyridinecarboxylate (D1, 460 mg, 2.0 mmol) in dioxane (4 ml) were added 4-hydroxy-phenyl boronic acid (414 mg, 3.0 mmol), Pd(PPh3)4 (450 mg, 0.4 mmol) and potassium carbonate (420 mg, 4.0 mmol) dissolved in water (2 ml). The reaction mixture was heated in a microwave synthesizer for 15 min at 150° C. The reaction mixture was diluted with ethyl acetate (150 ml) and washed with saturated aqueous ammonium chloride (40 ml). The resulting crude material was purified by chromatography on silica gel using ethyl acetate/cyclohexanes (1:1) to afford the title compound (340 mg, 72%); 1H-NMR (300 MHz, CDCl3) δ (ppm): 8.05 (d, 2H), 8.0 (m, 1H), 7.80 (d, 2H), 7.05 (d, 2H), 6.80 (bt, 1H), 4.50 (q, 2H), 1.45 (t, 3H).

Provenance & Evidence